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Interestingly, NKCC1 βKO mice also showed reduced satiation control to ad libitum feeding before developing overweight and a MetS-like phenotype (Rathod et al., 2023), consistent with the hypothesis that islets hormones participate in the control of food/energy intake (Woods et al., 2006)

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This in silico framework provides a platform from which GSH depletion can be explored as a function of a compound’s physicochemical properties