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These advances in disease mechanism research provide the basis for the design of drugs such as rapamycin (mTOR) inhibitors (tuberous sclerosis 22 and fragile X syndrome, 23,24 ) metabolic glutamate receptor (mGluR) antagonists (fragile X syndrome 25 and 16p11.2 deletion 26 ), and insulin growth factor (IGF-1) (Rett syndrome 27 and Phelan–McDermid syndrome 28,29 )