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A 2025 review of topically applied GHK as an anti-wrinkle peptide summarizes both the benefits and the honest limitation: skin penetration of the intact tripeptide is the bottleneck for topical formulations (PMID 39963574)

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On the other hand, by taking advantage of the fact that the present study encompasses a wide range of disease conditions, spanning from cancers to neuropsychiatric disorders, we propose that SFN may be a useful tool for examining the body-brain connection and that clinical trials with SFN may provide more insight into its biology