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Western blot analysis further confirmed SAC’s regulatory effects on the Keap1/Nrf2/GPX4 signaling pathway, showing elevated Nrf2, GPX4, NOQ1, HO1 and xCT protein levels and reduced Keap1 expression in the SAC group compared to the DSS group (Fig

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Potassium-Sparing Diuretics (e.g., Spironolactone, Amiloride): Act on the collecting duct, minimize potassium loss, often used in heart failure and hypertension