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Namely, without therapy, the rats with abdominal aorta anastomosis exhibited continuous severe painful muscle disability (either spontaneous or induced vocalization), very weak muscle strength and tottering walk, or even full inability to walk [129]

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It is also known that when CYP enzymes are induced by concomitant use with rifampicin (another anti-tuberculosis drug), the metabolic activation of isoniazid is promoted, increasing hepatotoxicity