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Interestingly, frameshift mutations disrupting the C-terminal DNA binding interface of PDS5B (c.3939dup and c.3954del) have been identified in gastrointestinal cancers 37 , underscoring the possible significance of the PDS5B DNA binding attribute in tumor suppression, and indicating that cancers harboring PDS5B mutations could be targeted with PARP inhibitors 38

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In inducing apoptosis in human lymphoma cells, Sag has shown to selectively activate programmed cell death in sensitive cell lines, providing evidence for its potential as a new inducer of lymphoma cell apoptosis