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Importantly, along with other clock proteins, REV-ERBα is subject to ubiquitin-dependent degradation by E3 ubiquitin ligases such as FBXW7 and UBE3A (Zhao et al., 2016), as discussed in more detail in Section “4 E3 ligases and deubiquitinating enzymes in circadian regulation.” 2.3 Turnover of core clock proteins The timed degradation of core clock proteins by the ubiquitin-proteasome system ensures proper cycling between repression and activation within the feedback loop, maintaining clock period length

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[DOI] [PubMed] [Google Scholar] 19.Lee YC, Lee KS, Park SJ, et al