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The risks include, but are not limited to: Development of primary pulmonary hypertension [see Warnings and Precautions (5.2)] Development of serious valvular heart disease [see Warnings and Precautions (5.3)] Effects on the ability to engage in potentially hazardous tasks [see Warnings and Precautions (5.5)] The risk of an increase in blood pressure [see Warnings and Precautions (5.8)andAdverse Reactions (6)] The risk of interactions [see Contraindications (4), Warnings and Precautions (5)andDrug Interactions (7)] See also, for example, Adverse Reactions (6)andUse in Specific Populations (8)