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Also, Wani et al., 2017 discovered that cannabis abusers had higher levels of total bilirubin, bilirubin direct, bilirubin indirect, aspartate amino transferase, alanine amino transferase, alkaline phosphate, and gamma-glutamyl transferase, and lower levels of total protein, albumin, and globulin, compared to the control group [48]
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It binds plasma proteins more tightly and hangs around longer, which is exactly why UK and European practice runs on 1 mg every two to three months for maintenance while American clinics default to monthly cyanocobalamin