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Proper titration, which requires accurate reconstitution, helps manage these by allowing gradual dose escalation rather than sudden jumps

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Notably, specimens from subjects with confirmed dementia diagnoses exhibited significantly elevated microplastic burden (26,076 μg/g median concentration), representing a five-fold increase compared to age-matched non-dementia controls—an association that remained statistically significant after multivariate adjustment for potential demographic and clinical confounders (53)