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J Neural Transm 121:1269–1272 [DOI] [PubMed] [Google Scholar] Liu D, Ke Z, Luo J (2017) Thiamine deficiency and neurodegeneration: the interplay among oxidative stress, endoplasmic reticulum stress, and autophagy
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R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)
