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Early nano-delivery systems such as liposomes and nanosuspensions initially suffered from storage instability (e.g., payload leakage and particle aggregation), but subsequent formulation optimization has greatly improved their robustness and yielded storage-stable products at scale (187, 188)

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Phase 1 (Weeks 1 to 2): 0.25 mg subcutaneous injection once daily, morning on empty stomach Phase 2 (Weeks 3 to 6): Maintain 0.25 mg or increase to 0.5 mg based on response and tolerance Phase 3 (Weeks 7 to 8): Continue or begin taper depending on symptom improvement Maintenance: Consider cycling 4 weeks on, 2 weeks off for long-term management Oral dosing requires higher amounts to compensate for bioavailability differences