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In this sense, it has been reported that miR-132 is negatively regulated by hypoxia, which increases MMP-9 activity, which degrades TJ proteins in brain endothelial cells or extracellular matrix components in the NVU, favoring an increased permeability of the BBB (Cichon et al., 2017)

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This method allowed the goodness of fit to inform upon an appropriate model structure when the actual reaction rates were unknown and, in doing so, provided a useful indication of the possible mechanism by which this process occurs