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Abstract In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications

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Transgenic mice with high constitutive VPAC2 expression in T cells showed immediate-type allergic reaction, in contrast to mice with knockout of the VPAC2 receptor [91,92,93]