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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways — incretin signalling, glucagon activity, and NAD+ metabolism — without clinical oversight introduces unpredictable physiological consequences

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The three reports of trichloroethylene exposure from the same group suggest that trichloroethylene increases VHL mutations and generates a unique genetic signature of trichloroethylene exposure, which leads to the development of renal cell carcinoma