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During vigorous muscle contraction or during fasting, ATP concentration decreases and AMP concentration increases leading to the activation of AMP-activated protein kinase (AMPK)

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Note that the used triple NO-agents’ application and BPC 157’s application as a simple but useful NO-key [11,29] shared the same dose relationship (L-NAME (5 mg/kg), L-arginine (100 mg/kg), BPC 157 (10 µg/kg)) in all BPC 157/NO-studies (for a review, see [11,29])