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(2020) investigate the effect of Oxoproline (Oxo), which, through the production of glutamic acid, provides an increase in intracellular folic acid trapping in moderate hyperhomocysteinemic (18.6 ± 2.4 μmol·L −1 ) patients suggesting that the use of oxoproline could be and intriguing alternative to traditional treatments for HHcy, when administered at doses below three grams per day, as approved by the European Food Safety Authority [75]