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Depletion in GSH is a common feature of apoptosis, which can be triggered by various stimuli, such as the activation of death receptors, stress, environmental factors, and cytotoxic drugs

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Additionally, a study by Liu et al (41) demonstrated that miR-196a promotes the development of non-small cell lung cancer by downregulating the expression of GPX3 and activating the JNK pathway, thereby enhancing the proliferation, differentiation, self-renewal ability and invasiveness of cancer stem cells (CSCs) (41)