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[22] have found that spermidine can promote melanogenesis in B16F10 cells, human melanoma MNT-1 cells, and primary human melanocytes MNT-1 by improving the stability of TRP-1 and TRP-2

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Before applying to live cells, the cytotoxicity of TPE-DCV is evaluated by using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay (Figure S13)