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Cancer stem cells have elevated levels of CD44 variants that have been shown to stabilize xCT, increasing cystine import and leading to increased intracellular glutathione levels (Ishimoto et al., 2011)

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A1298C Variant (rs1801131): While this variant has a smaller impact on homocysteine levels, it has been associated with neurotransmitter imbalances, mood disorders, and chronic fatigue [5]