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The inhibition or reversal of tachyphylaxis and fade by both ascorbate [70,71,72,73,74,75] and opioids [65,76,77] is mediated by increased cGMP production and concomitant inhibition of the G protein-mediated phosphorylation that down-regulates the receptor

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These findings suggest that ferroptosis-associated markers could be used clinically for disease monitoring and patient stratification and that ferroptosis-targeted therapies could serve as an exciting add-on to current treatment strategies to reduce secondary brain injury and promote long-term functional recovery (Table 4)