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The glutamate and cysteine can then feed into the GCL enzyme, however, in many cases, the enzyme is not functioning optimally or is damaged in some way, so it cannot increase the amount of Glyteine available for glutathione synthesis

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The accumulation of ROS has been demonstrated to trigger the phosphorylation and activation of the key kinase p38 MAPK, suggesting that ROS is a potential activator of the MAPK signaling pathway [75]