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2021;12 doi: 10.3389/fphar.2021.617714

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Additional Factors Promoting Enhanced Intestinal Permeability in Perimenopause Several common scenarios during perimenopause may contribute to increased EIP, amplifying inflammation and immune dysregulation: Chronic stress: Life-stage stressors, such as career pressures, family dynamics, caregiving responsibilities, poor sleep, and physical discomfort (achy muscles and joints), can elevate cortisol levels