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Microbes such as ( Streptococcus , Bifidobacterium , and Lactobacillus ) were used in the synthesis of probiotic strains associated with more positive treatment responses on GIT inflammation and the ability to maintain a better and healthier intestinal microbiota, and probiotics are often used to assess the efficacy of living microorganisms in reducing IBD manifestations (59)

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A 2025 review and patent analysis in Pharmaceuticals raised concerns specifically about the compound's pro-angiogenic and nitric-oxide-related activity