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Keywords: glutathione, mitochondria, oxidative phosphorylation, reactive oxygen species (ROS), programmed cell death, GSH deficiency, GSH/GSSG 1
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Choose Your Bundle:16oz | 1 Pack
The reason that could explain the poor infection outcome of GSH deficient mice is that the GSH:GSSG ratio directly affected the production of IL-12 from macrophages and this caused a reduction of IFN-γ production from NK or T cells, which could in turn activate the microbicidal activity of macrophages to kill the intracellular bacteria [104]