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Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour

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Sequence Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ Key Substitutions Include D‑Ala at position 2 to resist DPP‑IV cleavage Gln at position 8 to reduce deamidation Ala at position 15 to improve bioactivity Leu at position 27 to prevent oxidation Further Details Molecular Formula C₁₅₂H₂₅₂N₄₄O₄₂ Molecular Weight Approximately 3367–3368 Da CAS Number 863288-34-0 These molecular modifications improve stability and support consistent receptor interaction during laboratory experiments